Next-generation Micro-physiological system platform technology for disease modeling and drug testing

TECHNOLOGY

How to build physiologically relevant, advanced in vitro human models
in an easy and scalable way?
CELLSPACE provides a next-generation micro-physiological system platform technology for disease modeling and drug testing.
Our technology is based on a patented fluidic layout combined with
a 3D tilting apparatus to produce a directed gravity-driven flow without the need for pumps and tubes.
The platform enables the functional culture of multiple 3D organ models, endothelial cells, and the integration of circulating cells or particles. All these elements can be coupled together in different combinations in one microfluidic device, allowing the development of complex tissue and organ representations and advanced disease models.
Our pump-less approach still ensures high scalability and user-friendliness for drug discovery and drug testing in both academic and industrial R&D laboratories.

Product

Loop-in-Loop layout

The Loop-in-Loop layout adds a second perfusion channel loop and places two organ chambers between them. By adding a second perfusion loop, gradients can be generated and maintained within the organ chambers making this layout suitable to study vascularization, immune interaction, organogenesis, or cross-organ interaction. rOoCs with this layout are available:

a. Single chips (40×30 mm) fitting into a rectangular 8-Well plate.

b. Multiwell chips featuring 12 independent rOoCs at the footprint of a standard well and compatible with the 384-well grid layout for automated media exchange using a pipetting robot.

Product

Loop-in-Loop layout

The Loop-in-Loop layout adds a second perfusion channel loop and places two organ chambers between them. By adding a second perfusion loop, gradients can be generated and maintained within the organ chambers making this layout suitable to study vascularization, immune interaction, organogenesis, or cross-organ interaction. rOoCs with this layout are available:

a. Single chips (40×30 mm) fitting into a rectangular 8-Well plate.

b. Multiwell chips featuring 12 independent rOoCs at the footprint of a standard well and compatible with the 384-well grid layout for automated media exchange using a pipetting robot.

Single-use rOoC chips are available in different formats and configurations, optimized for organ models and biological questions. rOoC chips are shipped in a sterile, ready-to-use bag in different layouts 

Product

Loop-in-Loop layout

The Loop-in-Loop layout adds a second perfusion channel loop and places two organ chambers between them. By adding a second perfusion loop, gradients can be generated and maintained within the organ chambers making this layout suitable to study vascularization, immune interaction, organogenesis, or cross-organ interaction. rOoCs with this layout are available:

a. Single chips (40×30 mm) fitting into a rectangular 8-Well plate.

b. Multiwell chips featuring 12 independent rOoCs at the footprint of a standard well and compatible with the 384-well grid layout for automated media exchange using a pipetting robot.

Single-use rOoC chips are available in different formats and configurations, optimized for organ models and biological questions. rOoC chips are shipped in a sterile, ready-to-use bag in different layouts 

TEAM

CellSpace is an innovation project from Oslo, Norway that aims to spin out as a startup company from the Hybrid Technology Hub – Centre of Excellence at the University of Oslo. The technology has been developed by Mathias Busek (Ph.D.), who has more than 10 years of experience in the OoC field and pioneered an OoC platform with integrated pneumatic micro-pumps at TU Berlin (now used for drug screening by TissUse GmbH). He is leading the platform and technological developments at CellSpace. Biological use-cases development and incorporation of advanced 3D culture models into the platform is led by Alexandra Aizenshtadt (Ph.D.), who has both entrepreneur and academic experience (more than 10 years of experience in cell biology and disease modeling, and worked in interdisciplinary commercial and academic teams). The management team is complemented by Prof. Stefan Krauss, an international expert in
developmental biology and drug development with a broad experience in academic/industrial collaborations… The scientific team of CellSpace currently consists of Shadab Abadpour (Ph.D.) who has a solid background in pancreas biology and diabetes research, Mikel Amirola (Ph.D. candidate) working on stem-cell derived endothelial cells, Chengcheng Wang (Ph.D. candidate) an expert in stem-cell differentiation of islet organoids and Alexey Golovin responsible for chip manufacturing and quality control. The team will be supported by an Advisory Board. Current members are Hanne Scholz (Ph.D., Oslo University Hospital) with an extensive clinical experience in translational medicine, Ken Rosendal (Inven2) who assists in Business Development and Licensing, Aina Rengmark (Inven2) for administrative and legal support, and Tom Pike (CEO, Credio AS) is a board member in several Norwegian biotech and pharma companies thus has extensive knowledge of this industry to help us developing the project.

Management Team

Dr. Mathias Busek

Technical Dev

Dr. Aleksandra Aizenshtadt

Model Dev

Prof. Stefan Krauss

Advisor

Scientific Team

Dr. Mathias Busek

Model Dev

Chengcheng Wang

Model Dev

Mikel Amirola Martinez

Model Dev

Alexey Golovin

Technical Dev

ADVISORY BOARD

Dr. Hanna Scholtz

Regenerative Med.

Tom Pike

Pharma Industry

Ken Rosendal

BD

Dr. Aina Rengmark

BD & IP

contact

contact us

If you are interested in a collaboration or want more information about our products, please contact us.

© 2023 CELLSPACE I OSLO

contact

UNIVERSITETET I OSLO
Problemveien 7
0315 Oslo
Norway


Phone +47 22 85 50 50
E-Mail mail@uio.no

links

Webdesign + Programmierung: