New publication in Advanced Healthcare Materials featuring the rOoC platform
In the publication „Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver“, we are trying to address one of the major health issues worldwide: The global pandemic of metabolic disorders and type-2 diabetes:
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202303785
In the paper, we are able to establish a metabolic crosstalk between islet and liver organoids, can induce obesity with this insulin resistance of the liver organoids and finally treat the conditions with a panel of known drugs. This publication shows that the rOoC is a nice platform to study organ interaction, disease modelling and efficacy testing of drugs.